btki Archives - The MS Wire

News, info and tips for living with multiple sclerosis

Renewed Hope for BTK Inhibitor MS treatments

Posted on May 18, 2026May 17, 2026

Earlier this year, I wondered whether it was time to give up my hope that researchers were close to developing a Bruton tyrosine kinase (BTK) inhibitor – a treatment that could pump the brakes on multiple sclerosis (MS) progression, particularly in primary progressive MS (PPMS). The US Food and Drug Administration (FDA) had just decided not to approve the experimental BTK inhibitor tolebrutinib in its current form. But the findings…Continue Reading

BTK Inhibitors – The Next Big MS Therapy?

Posted on August 3, 2021August 2, 2021

Is orelabrutinib one of the next big MS therapies? Biogen is betting at least $125 million that it is. Orelabrutinib is an experimental oral BTK inhibitor (BTKi). BTKi’s are designed to selectively block an enzyme that’s important for the activation of B-cells and microglia. Some of those immune cells drive the abnormal immune responses that characterize MS. Researchers hope the medication will lower inflammation and slow progression of all forms…Continue Reading

"People newly diagnosed with MS will truly benefit from this book, while those of us who’ve lived with MS for a while will wish we’d had it ourselves!…Neurologists should consider keeping a copy of this book in their waiting room because their patients are going to need it." - Tamara K. Sellman, reviewing for Multiple Sclerosis.net.

The Multiple Sclerosis Toolbox is designed for MS "newbies" but it's great info for everyone. I combine more than 40 years of living with MS with some easy to understand info about diagnosis, treatments, visiting the neuro, relationships, mobility aids, travel and more…a lot of what you get in this blog. A paperback and an e-book are available on Amazon.