The MS Wire

News, info and tips for living with multiple sclerosis

Tag: btk inhibitor

A Little Stumble for BTKi’s

BTK's are molecules

A little over a year ago, I wrote about whether Bruton’s tyrosine kinase inhibitors (BTKi’s) might be the next big thing in multiple sclerosis (MS) treatments. BTKi’s are small molecules that selectively block an enzyme that’s important for the activation of B-cells in the immune system and microglia, cells whose job is to protect neurons. Some of both types of cells are thought to be responsible for the abnormal immune…Continue Reading

BTK Inhibitors – The Next Big MS Therapy?

btk inhibitor research

Is orelabrutinib one of the next big MS therapies? Biogen is betting at least $125 million that it is. Orelabrutinib is an experimental oral BTK inhibitor (BTKi). BTKi’s are designed to selectively block an enzyme that’s important for the activation of B-cells and microglia. Some of those immune cells drive the abnormal immune responses that characterize MS. Researchers hope the medication will lower inflammation and slow progression of all forms…Continue Reading